Vincent Hanlon

Vincent Hanlon

Postdoctoral Research Associate

Research group: Plant-parasitic interactions

Vincent Hanlon


I work on a hypervariable gene in plant-parasitic nematodes that is thought to have more than 1000 alleles. Strangely, these alleles seem not to be inherited but rather result from somatic rearrangements in just a few cells.

Before joining the Crop Science Centre, I did protocol development for single-cell DNA sequencing (Strand-seq), made an R package to detect and genotype inversions, co-developed a phasing technique that uses epigenetic imprinting to infer which parent alleles were inherited from, and estimated the rate at which heritable somatic mutations accumulate in Sitka spruce trees. I use a mix of bioinformatics, wet lab molecular biology, and (once upon a time) fieldwork.

I did my PhD with Peter Lansdorp, Diana Spierings, and Victor Guryev (University of Groningen / BC Cancer Research Centre; 2023), and I did my MSc with Sally Aitken (University of British Columbia; 2018). Before that I studied mathematics and philosophy (Queen’s University, Canada; 2014).



Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq.

Date: 11 January 2023

Contributors: Vahid Akbari, Vincent C.T. Hanlon, Kieran O’Neill, Louis Lefebvre, Kasmintan A. Schrader, Peter M. Lansdorp, Steven J.M. Jones

Journal: Cell Genomics


Chromosome-Length Haplotypes with StrandPhaseR and Strand-seq

Date: 7 November 2022

Contributors: Vincent C. T. Hanlon, David Porubsky & Peter M. Lansdorp

Journal: In Haplotyping : Methods and Protocols. New York, NY : Springer US


A survey of current methods to detect and genotype inversions

Date: 1 September 2022

Contributors: Vincent C. T. Hanlon, Peter M. Lansdorp, Victor Guryev

Journal: Human Mutation


Mapping of sister chromatid exchange events and genome alterations in single cells

Date: 27 May 2022

Contributors: Zeid Hamadeh, Vincent Hanlon, Peter M. Lansdorp

Journal: Methods


Benchmarking challenging small variants with linked and long reads

Date: 11 May 2022

Contributors: Justin Wagner, Nathan D. Olson, Lindsay Harris, Ziad Khan, Jesse Farek, Medhat Mahmoud, Ana Stankovic, Vladimir Kovacevic, Byunggil Yoo, Neil Miller, Jeffrey A. Rosenfeld, Bohan Ni, Samantha Zarate, Melanie Kirsche, Sergey Aganezov, Michael C. Schatz, Giuseppe Narzisi, Marta Byrska-Bishop, Wayne Clarke, Uday S. Evani, Justin M. Zook

Journal: Cell Genomics


Construction of Strand-seq libraries in open nanoliter arrays

Date: 24 January 2022

Contributors: Vincent C.T. Hanlon, Daniel D. Chan, Zeid Hamadeh, Yanni Wang, Carl-Adam Mattsson, Diana C.J. Spierings, Robin J.N. Coope, Peter M. Lansdorp

Journal: Cell Reports Methods


A phylogenomic approach reveals a low somatic mutation rate in a long-lived plant

Date: 11 March 2020

Contributors: Adam J. Orr, Amanda Padovan, David Kainer, Carsten Külheim, Lindell Bromham, Carlos Bustos-Segura, William Foley, Tonya Haff, Ji-Fan Hsieh, Alejandro Morales-Suarez, Reed A. Cartwright and Robert Lanfear

Journal: Evolution Letters

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