Ian Henderson
Head of the Genetic and Epigenetic Inheritance in Plants group
Biography
Ian is Professor of Genetics and Epigenetics in the Department of Plant Sciences at the University of Cambridge. Since 2008, his group has investigated genetic and epigenetic inheritance in plants, with a focus on meiosis and more recently on centromeres. Prior to arriving in Cambridge, Ian performed post-doctoral research with Prof. Steve Jacobsen (University of California Los Angeles, USA) studying RNA-directed in DNA methylation in Arabidopsis, and completed his PhD with Prof. Dame Caroline Dean (John Innes Centre, UK), where he investigated control of flowering-time by RNA binding proteins. He was elected a member of EMBO in 2022.
Publications
Publication
Structural variation and DNA methylation shape the centromere-proximal meiotic crossover landscape in Arabidopsis
Date: 22 January 2024
Contributors: Fernandes, J.B., Naish, M., Lian, Q., Burns, R., Tock, A.J., Rabanal F.A., Wlodzimierz, P., Habring, A., Nicholas, R.E., Weigel, D., Mercier, R. and Henderson, I.R.
Journal: Genome Biology
Publication
Cycles of satellite and retrotransposon evolution in Arabidopsis centromeres
Date: 17 May 2023
Contributors: Wlodzimierez, P, Rabanal, F., Burns, R., Naish, M., Primetis, E., Scott, A., Mandakova, T., Gorringe, N., Tock, A.J., Holland, D., Fritschi, K., Habring, A., Lanz, C., Patel, C., Schlegel, T., Collenberg, M., Mielke, M., Nordborg, M., Roux, F., Shirsekar, G., Alonso-Blanco, C., Lysak, M.A., Novikova, P., Bousios, A.W., Weigel, D.W. and Henderson, I.R.
Journal: Nature
Publication
Coexpression of MEIOTIC-TOPOISOMERASE VIB-dCas9 with guide RNAs specific to a recombination hotspot is insufficient to increase crossover frequency in Arabidopsis
Date: 7 July 2022
Contributors: Nataliya E Yelina, Daniel Holland, Sabrina Gonzalez-Jorge, Dominique Hirsz, Ziyi Yang, Ian R Henderson
Journal: G3 Genes|Genomes|Genetics
Publication
The genetic and epigenetic landscape of the Arabidopsis centromeres
Date: 12 November 2021
Contributors: Naish, M., Alonge, M., Wlodzimierez, P., Tock, A., Abramson, B., Schmucker, A., Mandakova, T., Bhagyshree, J., Lambing, C., Kuo, P., Yelina, N., Hartwick, N., Colt, K., Smith. L., Ton, J., Kakutani, K., Martienssen, R., Schneeberger, K., Lysak, M., Berger, F., Bousios, A., Michael, T., Schatz, M. and Henderson, I.R.
Journal: Science
Publication
ASY1 acts as a dosage-dependent antagonist of telomere-led recombination and mediates crossover interference in Arabidopsis’
Date: 4 June 2020
Contributors: Lambing, C.A., Kuo, P.C., Tock, A.J., Topp, S.D. and Henderson I.R.
Journal: Proceedings of the National Academy of Sciences USA
Publication
Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis
Date: 20 February 2018
Contributors: Serra, H., Lambing, C.A., Griffin, C.H., Topp, S.D., Nageswaran, D.C., Underwood, C.J., Ziolkowski, P.A., Seguela-Arnaud, M., Fernandes, J.B., Mercier, R. and Henderson, I.R.
Journal: Proceedings of the National Academy of Sciences USA
Publication
Quantification and Sequencing of Crossover Recombinant Molecules from Arabidopsis Pollen DNA
Date: 31 January 2017
Contributors: Kyuha Choi, Nataliya E. Yelina, Heïdi Serra & Ian R. Henderson
Journal: Methods in Molecular Biology
Publication
DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis
Date: 15 October 2015
Contributors: Nataliya E. Yelina, Christophe Lambing, Thomas J. Hardcastle, Xiaohui Zhao, Bruno Santos and Ian R. Henderson
Journal: Genes and Development
