Ian Henderson

Ian Henderson

Head of the Genetic and Epigenetic Inheritance in Plants group

Ian Henderson


Ian is Professor of Genetics and Epigenetics in the Department of Plant Sciences at the University of Cambridge. Since 2008, his group has investigated genetic and epigenetic inheritance in plants, with a focus on meiosis and more recently on centromeres. Prior to arriving in Cambridge, Ian performed post-doctoral research with Prof. Steve Jacobsen (University of California Los Angeles, USA) studying RNA-directed in DNA methylation in Arabidopsis, and completed his PhD with Prof. Dame Caroline Dean (John Innes Centre, UK), where he investigated control of flowering-time by RNA binding proteins. He was elected a member of EMBO in 2022.



Structural variation and DNA methylation shape the centromere-proximal meiotic crossover landscape in Arabidopsis

Date: 22 January 2024

Contributors: Fernandes, J.B., Naish, M., Lian, Q., Burns, R., Tock, A.J., Rabanal F.A., Wlodzimierz, P., Habring, A., Nicholas, R.E., Weigel, D., Mercier, R. and Henderson, I.R.

Journal: Genome Biology


Cycles of satellite and retrotransposon evolution in Arabidopsis centromeres

Date: 17 May 2023

Contributors: Wlodzimierez, P, Rabanal, F., Burns, R., Naish, M., Primetis, E., Scott, A., Mandakova, T., Gorringe, N., Tock, A.J., Holland, D., Fritschi, K., Habring, A., Lanz, C., Patel, C., Schlegel, T., Collenberg, M., Mielke, M., Nordborg, M., Roux, F., Shirsekar, G., Alonso-Blanco, C., Lysak, M.A., Novikova, P., Bousios, A.W., Weigel, D.W. and Henderson, I.R.

Journal: Nature


Coexpression of MEIOTIC-TOPOISOMERASE VIB-dCas9 with guide RNAs specific to a recombination hotspot is insufficient to increase crossover frequency in Arabidopsis

Date: 7 July 2022

Contributors: Nataliya E Yelina, Daniel Holland, Sabrina Gonzalez-Jorge, Dominique Hirsz, Ziyi Yang, Ian R Henderson

Journal: G3 Genes|Genomes|Genetics


The genetic and epigenetic landscape of the Arabidopsis centromeres

Date: 12 November 2021

Contributors: Naish, M., Alonge, M., Wlodzimierez, P., Tock, A., Abramson, B., Schmucker, A., Mandakova, T., Bhagyshree, J., Lambing, C., Kuo, P., Yelina, N., Hartwick, N., Colt, K., Smith. L., Ton, J., Kakutani, K., Martienssen, R., Schneeberger, K., Lysak, M., Berger, F., Bousios, A., Michael, T., Schatz, M. and Henderson, I.R.

Journal: Science


ASY1 acts as a dosage-dependent antagonist of telomere-led recombination and mediates crossover interference in Arabidopsis’

Date: 4 June 2020

Contributors: Lambing, C.A., Kuo, P.C., Tock, A.J., Topp, S.D. and Henderson I.R.

Journal: Proceedings of the National Academy of Sciences USA


Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis

Date: 20 February 2018

Contributors: Serra, H., Lambing, C.A., Griffin, C.H., Topp, S.D., Nageswaran, D.C., Underwood, C.J., Ziolkowski, P.A., Seguela-Arnaud, M., Fernandes, J.B., Mercier, R. and Henderson, I.R.

Journal: Proceedings of the National Academy of Sciences USA


Quantification and Sequencing of Crossover Recombinant Molecules from Arabidopsis Pollen DNA

Date: 31 January 2017

Contributors: Kyuha Choi, Nataliya E. Yelina, Heïdi Serra & Ian R. Henderson

Journal: Methods in Molecular Biology


DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis

Date: 15 October 2015

Contributors: Nataliya E. Yelina, Christophe Lambing, Thomas J. Hardcastle, Xiaohui Zhao, Bruno Santos and Ian R. Henderson

Journal: Genes and Development

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